A Complete multiplex solution for blood grouping

The versatility of SirYus-IH offers an easy transfer to existing lab workstations and could replace gel cards in a near future. The SirYus-IH technology’s breakthrough enables automated, fast and low-cost multiplex blood grouping tests

SirYus-IH is an innovative patented multiplex approach using hemagglutination principles. This method allows the complete blood grouping (ABO, D, IAT and RhKhell) using only 4 wells instead of tens. The process will require few microliters of samples with a time to result equivalent to gel cards.

 The SirYus-IH products consist of:

Test wells printed with anti-group antibodies for the in-parallel capture of red blood cells

• Reagents required for RBC dilutions and handling
• Tests are designed to run on gel cards workstations and enable to multiplex existing tests when using same reagents and consumables. 

	GEL CARD BASED ASSAY		ALTERNATIVE MULTIPLEXE APPROCHES
Sample needed	5 µL of red cell or 50 µL of plasma	<5 µL of red cell or <100 µL of plasma	3 µL of red cell or 80 µL of plasma
Buffer	LISS based buffer	Existing commercial buffer	Nd
Time to first result	< 10 min for direct and back typing, IAT or phenotyping	< 10 min for direct and back typing or phenotyping, 30min for IAT	35 min
Throughput	< 1000 samples/h	High versatility and easy adaptation on existing systems	>2000 samples/h
DEVICE
Format	6-8 Simplex tests	8 Multiplex tests	2 Multiplex tests cartridge
Material	Plastic	Plastic	Glass slide (Safety issue)
Shelf life		> 6 months	6 months
Waste, reagents and consumables	One set per plex	5 times less, average	5 times less average
COGS	Due to concept, SirYus is highly competitive